Binding sites for growth hormone-releasing peptide
نویسندگان
چکیده
منابع مشابه
Human renal cell carcinoma expresses distinct binding sites for growth hormone-releasing hormone.
Antagonists of growth hormone-releasing hormone (GHRH) inhibit the proliferation of various human cancers in vitro and in vivo by mechanisms that include apparent direct effects through specific binding sites expressed on tumors and that differ from pituitary human GHRH (hGHRH) receptors. In this study, GHRH antagonist JV-1-38 (20 microgram/day per animal s.c.) inhibited the growth of orthotopi...
متن کاملPhotoaffinity labeling of peptide hormone binding sites.
The known binding of a derivative of the COOH-terminal tetrapeptide of gastrin with high biological activity to bovine serum albumin suggests a convenient model system for testing the affinity labeling of hormone binding sites. Photolysis of 4-azidobenzoylpentagastrin, Z-nitro-5-azidobenzoylpentagastrin, 4-acetylbenzoylpentagastrin, and 4-benzoylbenzoylpentagastrin in the presence of bovine ser...
متن کاملGrowth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation.
GH-releasing peptide-6 (GHRP-6) is a potent GH secretagogue that releases GH by uncertain mechanisms. To assess whether GHRH is required for GH release by GHRP-6 in humans, we used the specific antagonist to GHRH (N-Ac-Tyr1,D-Arg2)GHRH(1-29)NH2 (GHRH Ant). We have previously shown that GHRH-Ant (400 microg/kg) blocked the GH response to 0.33 and 3.3 microg/kg boluses of GHRH by 95% and 81%, res...
متن کاملGrowth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice
OBJECTIVE To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormone-releasing hormone receptors. MATERIALS AND METHODS The responses of serum growth hormone to acutely injected growth hormone-releasing P-2 in lit/lit mice, which represent a model of ...
متن کاملIdentification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study.
The GHRPs (growth hormone-releasing peptides) are a class of small synthetic peptides known to stimulate GH release through binding of a G-protein-coupled receptor (designated GHS-R). We have found that hexarelin, a hexapeptide member of the GHRPs, binds to another protein identified as CD36, a scavenger receptor that is expressed in various tissues, including monocytes/macrophages and the endo...
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ژورنال
عنوان ژورنال: Growth Hormone & IGF Research
سال: 1998
ISSN: 1096-6374
DOI: 10.1016/s1096-6374(98)80038-5